The investigations of many psychologists and anthropologists support the generalization of there being little that is a significant difference in the underlying mental processes manifested by people from different cultures.
of there being little that is a significant difference
of there being little that is significantly different
of little that is significantly different
that there is little that is significantly different
that there is little of significant differences
ABC
this is just idiomatic. fortunately, it's pretty much consistent across the board for words that refer to things that people say or think. for example, you would use the same construction with the idea that..., the saying that..., etc..
some of these constructions can also work with "of" + noun, if that kind of thing makes sense in context. for instance, idea + of + noun can be used:
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