The investigations of many psychologists and anthropologists support the generalization of there being little that is a significant difference in the underlying mental processes manifested by people from different cultures.
of there being little that is a significant difference
of there being little that is significantly different
of little that is significantly different
that there is little that is significantly different
that there is little of significant differences
Generalization 后面that 同位语从句修饰这个整个概括的内容。 Idiomatic usage. In the phrase 'little of X', the X has to be a singular quantity. If it's plural (like 'differences'), then you have to use few.
There was very little food left over at the end of the party.
There were very few crab cakes left over at the end of the party.
in this sentence, "little" functions as a noun. you can use "much" in the same way: there is much that is different...
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