The investigations of many psychologists and anthropologists support the generalization of there being little that is a significant difference in the underlying mental processes manifested by people from different cultures.
of there being little that is a significant difference
of there being little that is significantly different
of little that is significantly different
that there is little that is significantly different
that there is little of significant differences
(E) In the phrase 'little of X', the X has to be a singular quantity. If it's plural (like 'differences'), then you have to use few.
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