The investigations of many psychologists and anthropologists support the generalization of there being little that is a significant difference in the underlying mental processes manifested by people from different cultures.
of there being little that is a significant difference
of there being little that is significantly different
of little that is significantly different
that there is little that is significantly different
that there is little of significant differences
'little of x' just means 'a small fraction of x'.
if 'x' is singular, and 'a small fraction of x' makes sense, then 'little of x' should also be fine. this issue is altogether unrelated to the idea of 'countable'/'uncountable', because it has nothing to do with counting.
e.g.,
I have read very little of this book.
I would not do well on the MCAT, because I have very little of the required knowledge.
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