Some patients who do not respond to therapies for depression may simply have received inadequate treatment, having, for example, been prescribed a drug at a dosage too low to be effective or having been taken off a drug too soon.
having, for example, been prescribed a drug at a dosage too low to be effective or having been
having, for example, a drug prescription that was ineffective because the dosage was too low, or being
as, for example, having too low of a dosage of a prescribed drug for it to be effective, or being
when they have, for example, been prescribed too low a drug dosage to be effective, or were
for example, when they have a drug prescription with a dosage too low to be effective, or been
choice b "having" + "was ineffective" doesn't make sense.
"having" adopts the same timeframe as the rest of the sentence -- which is the present (we can discern this by noticing that the sentence is talking about patients who do not respond). however, "was ineffective" seems to suggest that the prescription was ineffective sometime in the past.
taken together, these two contexts seem to indicate that the patient is, for some reason, holding onto an old prescription that was ineffective.
choice c would be incorrect because of Parallelism as well. Note that "as" creates a comparison, which is a special case of P-ism. Here the "as" connects "having too low a dosage" with "treatment." The same is the case with E, in a way, as the example give is not an example of a "treatment."
in choice d
1. "It" is ambiguous (original sentence without "It" sounds better)
2. Lack of parallelism "have been" not parallel to "were"
3. "too low a drug dosage" sounds awkwardly at least.
Choice d and e:"when" doesn't really work, because the sentence is talking about the things that are actually examples of inappropriate treatment.
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